Hepatocyte Insulin Signaling is Required for Feeding-Induced Lipogenesis but Dispensable for the Suppression of Glucose Production

Insulin-resistant syndromes such as type II diabetes mellitus (T2DM) involve disrupted temporal coordination of hepatic metabolism such that synthesis and secretion of lipid and glucose are inappropriately engaged concurrently. Here we test the hypothesis that a combination of direct and indirect ac...

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Veröffentlicht in:Cell Metab
Hauptverfasser: Titchenell, Paul M., Quinn, William J., Lu, Mingjian, Chu, Qingwei, Lu, Wenyun, Li, Changhong, Chen, Helen, Monks, Bobby R., Chen, Julia, Rabinowitz, Joshua D., Birnbaum, Morris J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909537/
https://ncbi.nlm.nih.gov/pubmed/27238637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.04.022
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