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Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
Considerable data support the idea that Foxo1 drives the liver transcriptional program during fasting and is inhibited by Akt after feeding. Mice with hepatic deletion of Akt1 and Akt2 were glucose intolerant, insulin resistant, and defective in the transcriptional response to feeding in liver. Thes...
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| Główni autorzy: | , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3296881/ https://ncbi.nlm.nih.gov/pubmed/22344295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2686 |
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