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Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

Considerable data support the idea that Foxo1 drives the liver transcriptional program during fasting and is inhibited by Akt after feeding. Mice with hepatic deletion of Akt1 and Akt2 were glucose intolerant, insulin resistant, and defective in the transcriptional response to feeding in liver. Thes...

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Main Authors: Lu, Mingjian, Wan, Min, Leavens, Karla F., Chu, Qingwei, Monks, Bobby R., Fernandez, Sully, Ahima, Rexford S., Ueki, Kohjiro, Kahn, C. Ronald, Birnbaum, Morris J.
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296881/
https://ncbi.nlm.nih.gov/pubmed/22344295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2686
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