The eukaryotic translation initiation factor eIF4E is a direct transcriptional target of NF-κB and is aberrantly regulated in Acute Myeloid Leukemia

The eukaryotic translation initiation factor eIF4E is a potent oncogene elevated in many cancers including the M4 and M5 subtypes of acute myeloid leukemia (AML). While eIF4E RNA levels are elevated 3–10 fold in M4/M5 AML, the molecular underpinnings of this dysregulation were unknown. Here, we demo...

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Enregistré dans:
Détails bibliographiques
Publié dans:Leukemia
Auteurs principaux: Hariri, Fadi, Arguello, Meztli, Volpon, Laurent, Culjkovic-Kraljacic, Biljana, Nielsen, Torsten Holm, Hiscott, John, Mann, Koren K., Borden, Katherine L.B.
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429918/
https://ncbi.nlm.nih.gov/pubmed/23467026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2013.73
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