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Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells
The repressive Hippo pathway has a profound tumour suppressive role in cancer by restraining the growth-promoting function of the transcriptional coactivator, YAP. We previously showed that the stem cell transcription factor Sox2 maintains cancer stem cells (CSCs) in osteosarcomas. We now report tha...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4429898/ https://ncbi.nlm.nih.gov/pubmed/25832504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7411 |
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