SOX2 Regulates YAP1 to Maintain Stemness and Determine Cell Fate in the Osteo-Adipo Lineage

The osteoblastic and adipocytic lineages arise from mesenchymal stem cells (MSCs), but few regulators of self-renewal and early cell-fate decisions are known. Here, we show that the Hippo pathway effector YAP1 is a direct target of SOX2 and can compensate for the self-renewal defect caused by SOX2 i...

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Bibliografiske detaljer
Udgivet i:Cell Rep
Main Authors: Seo, Eunjeong, Basu-Roy, Upal, Gunaratne, Preethi H., Coarfa, Cristian, Lim, Dae-Sik, Basilico, Claudio, Mansukhani, Alka
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053763/
https://ncbi.nlm.nih.gov/pubmed/23791527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.05.029
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