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LTB4 causes macrophage–mediated inflammation and directly induces insulin resistance in obesity
Chronic inflammation is a key component of obesity–induced insulin resistance and plays a central role in metabolic disease. In this study, we found that the major insulin target tissues, liver, muscle and adipose tissue exhibit increased levels of the chemotactic eicosanoid LTB4 in obese high fat d...
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| 發表在: | Nat Med |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4429798/ https://ncbi.nlm.nih.gov/pubmed/25706874 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3800 |
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