LTB4 causes macrophage–mediated inflammation and directly induces insulin resistance in obesity

Chronic inflammation is a key component of obesity–induced insulin resistance and plays a central role in metabolic disease. In this study, we found that the major insulin target tissues, liver, muscle and adipose tissue exhibit increased levels of the chemotactic eicosanoid LTB4 in obese high fat d...

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Detaylı Bibliyografya
Yayımlandı:Nat Med
Asıl Yazarlar: Li, Pingping, Oh, Da Young, Bandyopadhyay, Gautam, Lagakos, William S., Talukdar, Saswata, Osborn, Olivia, Johnson, Andrew, Chung, Heekyung, Maris, Michael, Ofrecio, Jachelle M., Taguchi, Sayaka, Lu, Min, Olefsky, Jerrold M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429798/
https://ncbi.nlm.nih.gov/pubmed/25706874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3800
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