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GPR105 ablation prevents inflammation and improves insulin sensitivity in mice with diet-induced obesity
GPR105, a G-protein coupled receptor for UDP-glucose, is highly expressed in several human tissues and participates in the innate immune response. Since inflammation has been implicated as a key initial trigger for type 2 diabetes, we hypothesized that GPR105 (official gene name: P2RY14) might play...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3411902/ https://ncbi.nlm.nih.gov/pubmed/22778393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1103207 |
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