G protein–coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice

Obesity-induced inflammation is a key component of systemic insulin resistance, which is a hallmark of type 2 diabetes. A major driver of this inflammation/insulin resistance syndrome is the accumulation of proinflammatory macrophages in adipose tissue and liver. We found that the orphan GPCR Gpr21...

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Autors principals: Osborn, Olivia, Oh, Da Young, McNelis, Joanne, Sanchez-Alavez, Manuel, Talukdar, Saswata, Lu, Min, Li, PingPing, Thiede, Lucinda, Morinaga, Hidetaka, Kim, Jane J., Heinrichsdorff, Jan, Nalbandian, Sarah, Ofrecio, Jachelle M., Scadeng, Miriam, Schenk, Simon, Hadcock, John, Bartfai, Tamas, Olefsky, Jerrold M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386820/
https://ncbi.nlm.nih.gov/pubmed/22653059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI61953
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