LTB4 causes macrophage–mediated inflammation and directly induces insulin resistance in obesity

Chronic inflammation is a key component of obesity–induced insulin resistance and plays a central role in metabolic disease. In this study, we found that the major insulin target tissues, liver, muscle and adipose tissue exhibit increased levels of the chemotactic eicosanoid LTB4 in obese high fat d...

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Udgivet i:Nat Med
Main Authors: Li, Pingping, Oh, Da Young, Bandyopadhyay, Gautam, Lagakos, William S., Talukdar, Saswata, Osborn, Olivia, Johnson, Andrew, Chung, Heekyung, Maris, Michael, Ofrecio, Jachelle M., Taguchi, Sayaka, Lu, Min, Olefsky, Jerrold M.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429798/
https://ncbi.nlm.nih.gov/pubmed/25706874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3800
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