Arsenic and chromium in drinking water promote tumorigenesis in a mouse colitis-associated colorectal cancer model and the potential mechanism is ROS-mediated Wnt/β-catenin signaling pathway

Exposure to carcinogenic metals, such as trivalent arsenic [As(III)] and hexavalent chromium [Cr(VI)], through drinking water is a major global public health problem and is associated with various cancers. However, the mechanism of their carcinogenicity remains unclear. In this study, we used azoxym...

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Udgivet i:Toxicol Appl Pharmacol
Main Authors: Wang, Xin, Mandal, Ardhendu K., Saito, Hiroshi, Pulliam, Joseph F., Lee, Eun Y., Ke, Zun-Ji, Lu, Jian, Ding, Songze, Li, Li, Shelton, Brent J, Tucker, Thomas, Evers, B. Mark, Zhang, Zhuo, Shi, Xianglin
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429765/
https://ncbi.nlm.nih.gov/pubmed/22552367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2012.04.014
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