Farnesoid X receptor antagonizes Wnt/β-catenin signaling in colorectal tumorigenesis

Farnesoid X receptor (FXR, encoded by NR1H4), a critical regulator of bile acid homeostasis, is widely implicated in human tumorigenesis. However, the functional role of FXR in colorectal cancer (CRC) and the precise molecular mechanism remain unclear. In this study, we demonstrated that FXR express...

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Vydáno v:Cell Death Dis
Hlavní autoři: Yu, Junhui, Li, Shan, Guo, Jing, Xu, Zhengshui, Zheng, Jianbao, Sun, Xuejun
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7431544/
https://ncbi.nlm.nih.gov/pubmed/32807788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02819-w
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