Anti-Inflammatory Effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1S, a Selective c-Jun N-Terminal Kinase Inhibitor

c-Jun N-terminal kinases (JNKs) participate in many physiologic and pathologic processes, including inflammatory diseases. We recently synthesized the sodium salt of IQ-1S (11H-indeno[1,2-b]quinoxalin-11-one oxime) and demonstrated that it is a high-affinity JNK inhibitor and inhibits murine delayed...

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Publicado en:J Pharmacol Exp Ther
Autores principales: Schepetkin, Igor A., Kirpotina, Liliya N., Hammaker, Deepa, Kochetkova, Irina, Khlebnikov, Andrei I., Lyakhov, Sergey A., Firestein, Gary S., Quinn, Mark T.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2015
Materias:
Inflammation, Immunopharmacology, and Asthma
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429673/
https://ncbi.nlm.nih.gov/pubmed/25784649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.220251
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