Identification and Characterization of a Novel Class of c-Jun N-terminal Kinase Inhibitors

In efforts to identify novel small molecules with anti-inflammatory properties, we discovered a unique series of tetracyclic indenoquinoxaline derivatives that inhibited lipopolysaccharide (LPS)-induced nuclear factor-κB/activating protein 1 activation. Compound IQ-1 (11H-indeno[1,2-b]quinoxalin-11-...

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Main Authors: Schepetkin, Igor A., Kirpotina, Liliya N., Khlebnikov, Andrei I., Hanks, Tracey S., Kochetkova, Irina, Pascual, David W., Jutila, Mark A., Quinn, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362897/
https://ncbi.nlm.nih.gov/pubmed/22434859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.077446
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