Vascular endothelial growth factor blockade alters magnetic resonance imaging biomarkers of vascular function and decreases barrier permeability in a rat model of lung cancer brain metastasis

BACKGROUND: Blockade of vascular endothelial growth factor (VEGF) to promote vascular normalization and inhibit angiogenesis has been proposed for the treatment of brain metastases; however, vascular normalization has not been well-characterized in this disease. We investigated the effect of treatme...

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Detalhes bibliográficos
Publicado no:Fluids Barriers CNS
Main Authors: Pishko, Gregory L, Muldoon, Leslie L, Pagel, Michael A, Schwartz, Daniel L, Neuwelt, Edward A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429592/
https://ncbi.nlm.nih.gov/pubmed/25879723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-8118-12-5
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