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Quantifying and Communicating Uncertainty in Preclinical Human Dose-Prediction
Human dose-prediction is fundamental for ranking lead-optimization compounds in drug discovery and to inform design of early clinical trials. This tutorial describes how uncertainty in such predictions can be quantified and efficiently communicated to facilitate decision-making. Using three drug-dis...
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| Publicado no: | CPT Pharmacometrics Syst Pharmacol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4429578/ https://ncbi.nlm.nih.gov/pubmed/26225248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.32 |
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