ROS-mediated iron overload injures the hematopoiesis of bone marrow by damaging hematopoietic stem/progenitor cells in mice

Iron overload, caused by hereditary hemochromatosis or repeated blood transfusions in some diseases, such as beta thalassemia, bone marrow failure and myelodysplastic syndrome, can significantly induce injured bone marrow (BM) function as well as parenchyma organ dysfunctions. However, the effect of...

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Udgivet i:Sci Rep
Main Authors: Chai, Xiao, Li, Deguan, Cao, Xiaoli, Zhang, Yuchen, Mu, Juan, Lu, Wenyi, Xiao, Xia, Li, Chengcheng, Meng, Juanxia, Chen, Jie, Li, Qing, Wang, Jishi, Meng, Aimin, Zhao, Mingfeng
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429544/
https://ncbi.nlm.nih.gov/pubmed/25970748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10181
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