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ROS-mediated iron overload injures the hematopoiesis of bone marrow by damaging hematopoietic stem/progenitor cells in mice

Iron overload, caused by hereditary hemochromatosis or repeated blood transfusions in some diseases, such as beta thalassemia, bone marrow failure and myelodysplastic syndrome, can significantly induce injured bone marrow (BM) function as well as parenchyma organ dysfunctions. However, the effect of...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Chai, Xiao, Li, Deguan, Cao, Xiaoli, Zhang, Yuchen, Mu, Juan, Lu, Wenyi, Xiao, Xia, Li, Chengcheng, Meng, Juanxia, Chen, Jie, Li, Qing, Wang, Jishi, Meng, Aimin, Zhao, Mingfeng
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429544/
https://ncbi.nlm.nih.gov/pubmed/25970748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10181
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