Error-prone replication of repeated DNA sequences by T7 DNA polymerase in the absence of its processivity subunit.

We have examined the effect of thioredoxin, an accessory protein that confers high processivity to bacteriophage T7 DNA polymerase, on the fidelity of DNA synthesis. In the presence of thioredoxin, exonuclease-proficient T7 DNA polymerase is highly accurate. In fidelity assays that score errors that...

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Argitaratua izan da:	Proc Natl Acad Sci U S A
Egile Nagusiak:	Kunkel, T A, Patel, S S, Johnson, K A
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	National Academy of Sciences 1994
Gaiak:	Research Article
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44291/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8041704/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.15.6830
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