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Characterization of Mutants of Human Small Heat Shock Protein HspB1 Carrying Replacements in the N-Terminal Domain and Associated with Hereditary Motor Neuron Diseases

Physico-chemical properties of the mutations G34R, P39L and E41K in the N-terminal domain of human heat shock protein B1 (HspB1), which have been associated with hereditary motor neuron neuropathy, were analyzed. Heat-induced aggregation of all mutants started at lower temperatures than for the wild...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Muranova, Lydia K., Weeks, Stephen D., Strelkov, Sergei V., Gusev, Nikolai B.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429025/
https://ncbi.nlm.nih.gov/pubmed/25965061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126248
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