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Effect of methylglyoxal modification on the structure and properties of human small heat shock protein HspB6 (Hsp20)

Human small heat shock protein HspB6 (Hsp20) was modified by metabolic α-dicarbonyl compound methylglyoxal (MGO). At low MGO/HspB6 molar ratio, Arg13, Arg14, Arg27, and Arg102 were the primary sites of MGO modification. At high MGO/HspB6 ratio, practically, all Arg and Lys residues of HspB6 were mod...

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Detalhes bibliográficos
Publicado no:Cell Stress Chaperones
Main Authors: Muranova, Lydia K., Perfilov, Maxim M., Serebryakova, Marina V., Gusev, Nikolai B.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907992/
https://ncbi.nlm.nih.gov/pubmed/27061807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-016-0686-4
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