Effect of methylglyoxal modification on the structure and properties of human small heat shock protein HspB6 (Hsp20)

Human small heat shock protein HspB6 (Hsp20) was modified by metabolic α-dicarbonyl compound methylglyoxal (MGO). At low MGO/HspB6 molar ratio, Arg13, Arg14, Arg27, and Arg102 were the primary sites of MGO modification. At high MGO/HspB6 ratio, practically, all Arg and Lys residues of HspB6 were mod...

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Vydáno v:Cell Stress Chaperones
Hlavní autoři: Muranova, Lydia K., Perfilov, Maxim M., Serebryakova, Marina V., Gusev, Nikolai B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Netherlands 2016
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Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907992/
https://ncbi.nlm.nih.gov/pubmed/27061807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-016-0686-4
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