Pharmacological Characterization of an Antisense Knockdown Zebrafish Model of Dravet Syndrome: Inhibition of Epileptic Seizures by the Serotonin Agonist Fenfluramine

Dravet syndrome (DS) is one of the most pharmacoresistant and devastating forms of childhood epilepsy syndromes. Distinct de novo mutations in the SCN1A gene are responsible for over 80% of DS cases. While DS is largely resistant to treatment with existing anti-epileptic drugs, promising results hav...

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Udgivet i:PLoS One
Main Authors: Zhang, Yifan, Kecskés, Angéla, Copmans, Daniëlle, Langlois, Mélanie, Crawford, Alexander D., Ceulemans, Berten, Lagae, Lieven, de Witte, Peter A. M., Esguerra, Camila V.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428833/
https://ncbi.nlm.nih.gov/pubmed/25965391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125898
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