"Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure.

Platelet activation by thrombin plays a critical role in hemostasis and thrombosis. Based on structure-activity studies of a cloned platelet thrombin receptor, we designed two "mirror image" antagonists of thrombin and thrombin receptor function. First, "uncleavable" peptides mimicking the receptor...

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Detalles Bibliográficos

Publicado en:	J Clin Invest
Autores principales:	Hung, D T, Vu, T K, Wheaton, V I, Charo, I F, Nelken, N A, Esmon, N, Esmon, C T, Coughlin, S R
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Clinical Investigation 1992
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442871/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1310695/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115604
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