"Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure.

Platelet activation by thrombin plays a critical role in hemostasis and thrombosis. Based on structure-activity studies of a cloned platelet thrombin receptor, we designed two "mirror image" antagonists of thrombin and thrombin receptor function. First, "uncleavable" peptides mim...

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Bibliografiske detaljer
Main Authors: Hung, D T, Vu, T K, Wheaton, V I, Charo, I F, Nelken, N A, Esmon, N, Esmon, C T, Coughlin, S R
Format: Artigo
Sprog:Inglês
Udgivet: 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC442871/
https://ncbi.nlm.nih.gov/pubmed/1310695
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