TCR ITAM multiplicity is required for the generation of follicular helper T-cells

The T-cell antigen receptor (TCR) complex contains 10 copies of a di-tyrosine Immunoreceptor-Tyrosine-based-Activation-Motif (ITAM) that initiates TCR signalling by recruiting protein tyrosine kinases. ITAM multiplicity amplifies TCR signals, but the importance of this capability for T-cell response...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hwang, SuJin, Palin, Amy C., Li, LiQi, Song, Ki-Duk, Lee, Jan, Herz, Jasmin, Tubo, Noah, Chu, Hamlet, Pepper, Marion, Lesourne, Renaud, Zvezdova, Ekaterina, Pinkhasov, Julia, Jenkins, Marc K., McGavern, Dorian, Love, Paul E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428620/
https://ncbi.nlm.nih.gov/pubmed/25959494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7982
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