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Allosteric regulation of deubiquitylase activity through ubiquitination
Ataxin-3, the protein responsible for spinocerebellar ataxia type-3, is a cysteine protease that specifically cleaves poly-ubiquitin chains and participates in the ubiquitin proteasome pathway. The enzymatic activity resides in the N-terminal Josephin domain. An unusual feature of ataxin-3 is its lo...
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| Publicado no: | Front Mol Biosci |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4428445/ https://ncbi.nlm.nih.gov/pubmed/25988170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2015.00002 |
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