Allosteric regulation of deubiquitylase activity through ubiquitination

Ataxin-3, the protein responsible for spinocerebellar ataxia type-3, is a cysteine protease that specifically cleaves poly-ubiquitin chains and participates in the ubiquitin proteasome pathway. The enzymatic activity resides in the N-terminal Josephin domain. An unusual feature of ataxin-3 is its lo...

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Publicat a:Front Mol Biosci
Autors principals: Faggiano, Serena, Menon, Rajesh P., Kelly, Geoff P., Todi, Sokol V., Scaglione, K. Matthew, Konarev, Petr V., Svergun, Dmitri I., Paulson, Henry L., Pastore, Annalisa
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2015
Matèries:
Molecular Biosciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428445/
https://ncbi.nlm.nih.gov/pubmed/25988170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2015.00002
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