Serum-stabilized Naked Caspase-3 siRNA Protects Autotransplant Kidneys in a Porcine Model

The naked small interfering RNA (siRNA) of caspase-3, a key player in ischemia reperfusion injury, was effective in cold preserved and hemoreperfused kidneys, but not autotransplanted kidneys in our porcine models. Here, chemically modified serum stabilized caspase-3 siRNAs were further evaluated. T...

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Detalles Bibliográficos
Publicado en:Mol Ther
Main Authors: Yang, Cheng, Zhao, Tian, Zhao, Zitong, Jia, Yichen, Li, Long, Zhang, Yufang, Song, Mangen, Rong, Ruiming, Xu, Ming, Nicholson, Michael L, Zhu, Tongyu, Yang, Bin
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2014
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428396/
https://ncbi.nlm.nih.gov/pubmed/24930602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.111
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