Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway

BACKGROUND: We previously reported the identification of ONC201/TIC10, a novel small molecule inducer of the human TRAIL gene that improves efficacy-limiting properties of recombinant TRAIL and is in clinical trials in advanced cancers based on its promising safety and antitumor efficacy in several...

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Detalles Bibliográficos
Publicado en:Mol Cancer
Autores principales: Allen, Joshua E, Krigsfeld, Gabriel, Patel, Luv, Mayes, Patrick A, Dicker, David T, Wu, Gen Sheng, El-Deiry, Wafik S
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428111/
https://ncbi.nlm.nih.gov/pubmed/25927855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0346-9
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