Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway

BACKGROUND: We previously reported the identification of ONC201/TIC10, a novel small molecule inducer of the human TRAIL gene that improves efficacy-limiting properties of recombinant TRAIL and is in clinical trials in advanced cancers based on its promising safety and antitumor efficacy in several...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Mol Cancer
Main Authors: Allen, Joshua E, Krigsfeld, Gabriel, Patel, Luv, Mayes, Patrick A, Dicker, David T, Wu, Gen Sheng, El-Deiry, Wafik S
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central 2015
נושאים:
Research
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428111/
https://ncbi.nlm.nih.gov/pubmed/25927855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0346-9
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