Stella preserves maternal chromosome integrity by inhibiting 5hmC-induced γH2AX accumulation

In the mouse zygote, Stella/PGC7 protects 5-methylcytosine (5mC) of the maternal genome from Tet3-mediated oxidation to 5-hydroxymethylcytosine (5hmC). Although ablation of Stella causes early embryonic lethality, the underlying molecular mechanisms remain unknown. In this study, we report impaired...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Nakatani, Tsunetoshi, Yamagata, Kazuo, Kimura, Tohru, Oda, Masaaki, Nakashima, Hiroyuki, Hori, Mayuko, Sekita, Yoichi, Arakawa, Tatsuhiko, Nakamura, Toshinobu, Nakano, Toru
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428038/
https://ncbi.nlm.nih.gov/pubmed/25694116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201439427
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