BRAF- and MEK-Targeted Small Molecule Inhibitors Exert Enhanced Antimelanoma Effects in Combination With Oncolytic Reovirus Through ER Stress

Reovirus type 3 (Dearing) (RT3D) infection is selective for cells harboring a mutated/activated RAS pathway. Therefore, in a panel of melanoma cell lines (including RAS mutant, BRAF mutant and RAS/BRAF wild-type), we assessed therapeutic combinations that enhance/suppress ERK1/2 signaling through us...

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Pubblicato in:Mol Ther
Autori principali: Roulstone, Victoria, Pedersen, Malin, Kyula, Joan, Mansfield, David, Khan, Aadil A, McEntee, Grainne, Wilkinson, Michelle, Karapanagiotou, Eleni, Coffey, Matt, Marais, Richard, Jebar, Adel, Errington-Mais, Fiona, Melcher, Alan, Vile, Richard, Pandha, Hardev, McLaughlin, Martin, Harrington, Kevin J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427871/
https://ncbi.nlm.nih.gov/pubmed/25619724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.15
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