SoNar, a highly responsive NAD(+)/NADH sensor, allows high-throughput metabolic screening of anti-tumor agents

The altered metabolism of tumor cells confers a selective advantage for survival and proliferation, and studies have shown that targeting such metabolic shifts may be a useful therapeutic strategy. We developed an intensely fluorescent, rapidly responsive, pH-resistant, genetically encoded sensor of...

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Vydáno v:Cell Metab
Hlavní autoři: Zhao, Yuzheng, Hu, Qingxun, Cheng, Feixiong, Su, Ni, Wang, Aoxue, Zou, Yejun, Hu, Hanyang, Chen, Xianjun, Zhou, Hai-Meng, Huang, Xinzhi, Yang, Kai, Zhu, Qian, Wang, Xue, Yi, Jing, Zhu, Linyong, Qian, Xuhong, Chen, Lixin, Tang, Yun, Loscalzo, Joseph, Yang, Yi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427571/
https://ncbi.nlm.nih.gov/pubmed/25955212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.04.009
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