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The Activity of Quinolone CP-115,955 Against Bacterial and Human Type II Topoisomerases Is Mediated by Different Interactions

CP-115,955 is a quinolone with a 4-hydroxyphenyl at C7 that displays high activity against both bacterial and human type II topoisomerases. To determine the basis for quinolone cross-reactivity between bacterial and human enzymes, the activity of CP-115,955 and a series of related quinolones and qui...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Aldred, Katie J., Schwanz, Heidi A., Li, Gangqin, Williamson, Benjamin H., McPherson, Sylvia A., Turnbough, Charles L., Kerns, Robert J., Osheroff, Neil
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427193/
https://ncbi.nlm.nih.gov/pubmed/25586498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501073v
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