Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: A potential model for study of defective copper regulation in metabolic liver disease

Ob/ob mice provide an animal model for non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH) in patients with obesity and type-2 diabetes. Low liver copper has been linked to hepatic lipid build-up (steatosis) in animals with systemic copper deficiency caused by low-copper die...

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Publicado no:Biochem Biophys Res Commun
Main Authors: Church, Stephanie J., Begley, Paul, Kureishy, Nina, McHarg, Selina, Bishop, Paul N., Bechtold, David A., Unwin, Richard D., Cooper, Garth J.S.
Formato: Artigo
Idioma:Inglês
Publicado em: Academic Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427106/
https://ncbi.nlm.nih.gov/pubmed/25797622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2015.03.067
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