Broad and persistent Gag-specific CD8+ T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection

OBJECTIVE: We characterized protein-specific CD8+ T-cell immunodominance patterns during the first year of HIV-1 infection, and their impact on viral evolution and immune control. METHODS: We analyzed CD8+ T-cell responses to the full HIV-1 proteome during the first year of infection in eighteen ant...

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Enregistré dans:
Détails bibliographiques
Publié dans:AIDS
Auteurs principaux: Radebe, Mopo, Gounder, Kamini, Mokgoro, Mammekwa, Ndhlovu, Zaza M., Mncube, Zenele, Mkhize, Lungile, van der Stok, Mary, Jaggernath, Manjeetha, Walker, Bruce D., Ndung’u, Thumbi
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427042/
https://ncbi.nlm.nih.gov/pubmed/25387316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000000508
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