Triptolide and its prodrug minnelide suppress Hsp70 and inhibit in vivo growth in a xenograft model of mesothelioma

Malignant mesothelioma is a devastating disease with a poor prognosis for which there is a clear need for more successful therapeutic approaches. Triptolide, a diterpenoid triepoxide, is a highly effective agent against several cancer types in animal models. Owing to triptolide's poor solubilit...

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Detalhes bibliográficos
Publicado no:Genes Cancer
Main Authors: Jacobson, Blake A., Chen, Esther Z., Tang, Shaogeng, Belgum, Holly Sedgwick, McCauley, Joel A., Evenson, Kristen A., Etchison, Ryan G., Jay-Dixon, Joe, Patel, Manish R., Raza, Ahmad, Saluja, Ashok K., D'Cunha, Jonathan, Kratzke, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426951/
https://ncbi.nlm.nih.gov/pubmed/26000097
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