Defective processing of insulin-receptor precursor in cultured lymphocytes from a patient with extreme insulin resistance.

We have studied a patient with extreme insulin resistance, acanthosis nigricans, and decreased erythrocyte insulin binding. EBV-transformed lymphocytes from this patient exhibited markedly reduced binding of 125I-insulin. Radioiodination of cell surface receptors followed by immunoprecipitation with...

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Detalhes bibliográficos
Main Authors: Kakehi, T, Hisatomi, A, Kuzuya, H, Yoshimasa, Y, Okamoto, M, Yamada, K, Nishimura, H, Kosaki, A, Nawata, H, Umeda, F
Formato: Artigo
Idioma:Inglês
Publicado em: 1988
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC442658/
https://ncbi.nlm.nih.gov/pubmed/3384956
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