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Error-free and mutagenic processing of topoisomerase 1-provoked damage at genomic ribonucleotides
Genomic ribonucleotides incorporated during DNA replication are commonly repaired by RNase H2-dependent ribonucleotide excision repair (RER). When RNase H2 is compromised, such as in Aicardi-Goutières patients, genomic ribonucleotides either persist or are processed by DNA topoisomerase 1 (Top1) by...
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| Publicado no: | EMBO J |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4426484/ https://ncbi.nlm.nih.gov/pubmed/25777529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490868 |
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