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Buried ionizable networks are an ancient hallmark of G protein-coupled receptor activation
Seven-transmembrane receptors (7TMRs) have evolved in prokaryotes and eukaryotes over hundreds of millions of years. Comparative structural analysis suggests that these receptors may share a remote evolutionary origin, despite their lack of sequence similarity. Here we used structure-based computati...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4426463/ https://ncbi.nlm.nih.gov/pubmed/25902551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417888112 |
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