Polymerization of sickle cell hemoglobin at arterial oxygen saturation impairs erythrocyte deformability.

We have examined the filterability of sickle erythrocytes, using an initial-flow-rate method, to determine whether sufficient hemoglobin S polymer forms at arterial oxygen saturation to adversely affect erythrocyte deformability. The amount of intracellular polymer was calculated as a function of ox...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Green, M A, Noguchi, C T, Keidan, A J, Marwah, S S, Stuart, J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1988
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442609/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3384944/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113504
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