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Polymerization of sickle cell hemoglobin at arterial oxygen saturation impairs erythrocyte deformability.

We have examined the filterability of sickle erythrocytes, using an initial-flow-rate method, to determine whether sufficient hemoglobin S polymer forms at arterial oxygen saturation to adversely affect erythrocyte deformability. The amount of intracellular polymer was calculated as a function of ox...

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Bibliographic Details
Main Authors: Green, M A, Noguchi, C T, Keidan, A J, Marwah, S S, Stuart, J
Format: Artigo
Language:Inglês
Published: 1988
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC442609/
https://ncbi.nlm.nih.gov/pubmed/3384944
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