Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells

Although many chemotherapeutic strategies against cancer have been developed, pancreatic cancer is one of the most aggressive and intractable types of malignancies. Therefore, new strategies and anti-cancer agents are necessary to treat this disease. Metformin is a widely used drug for type-2 diabet...

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Udgivet i:PLoS One
Main Authors: Tanaka, Ryoichi, Tomosugi, Mitsuhiro, Horinaka, Mano, Sowa, Yoshihiro, Sakai, Toshiyuki
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4425682/
https://ncbi.nlm.nih.gov/pubmed/25955843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125779
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