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Adenovirus-Mediated Expression of Truncated E2F-1 Suppresses Tumor Growth In Vitro and In Vivo
BACKGROUND: Adenovirus (Ad)-mediated E2F-1 gene transfer induces apoptosis in cancer cells in vitro and in vivo, but clinical application of E2F-1 in cancer gene therapy remains controversial because of the oncogenic potential of E2F-1. This barrier can be circumvented by using the truncated form of...
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| Publicado no: | Cancer |
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| Principais autores: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4425364/ https://ncbi.nlm.nih.gov/pubmed/20549818 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.25322 |
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