TALEN-Mediated Gene Disruption on Y Chromosome Reveals Critical Role of EIF2S3Y in Mouse Spermatogenesis

The Y chromosome plays a critical role in spermatogenesis. Formerly, it had been difficult to generate knockout mice with specific Y chromosome mutations using conventional gene-targeting strategies. Recently, a transcription activator-like effector nuclease (TALEN) was successfully used for editing...

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Bibliographische Detailangaben
Veröffentlicht in:Stem Cells Dev
Hauptverfasser: Matsubara, Yohei, Kato, Tomoko, Kashimada, Kenichi, Tanaka, Hiromitsu, Zhi, Zhou, Ichinose, Shizuko, Mizutani, Shuki, Morio, Tomohiro, Chiba, Tomoki, Ito, Yoshiaki, Saga, Yumiko, Takada, Shuji, Asahara, Hiroshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2015
Schlagworte:
Original Research Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4425228/
https://ncbi.nlm.nih.gov/pubmed/25579647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2014.0466
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