FOXL2 transcriptionally represses Sf1 expression by antagonizing WT1 during ovarian development in mice

Steroidogenic factor 1 (SF1; Ad4BP/NR5A1) plays key roles in gonadal development. Initially, the Sf1 gene is expressed in mouse fetal gonads of both sexes, but later is up-regulated in testes and down-regulated in ovaries. While Sf1 expression is activated and maintained by Wilms tumor 1 (WT1) and L...

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Detalhes bibliográficos
Main Authors: Takasawa, Kei, Kashimada, Kenichi, Pelosi, Emanuele, Takagi, Masatoshi, Morio, Tomohiro, Asahara, Hiroshi, Schlessinger, David, Mizutani, Shuki, Koopman, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2014
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986836/
https://ncbi.nlm.nih.gov/pubmed/24451388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-246108
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