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Synaptic Dysfunction in Depression: Potential Therapeutic Targets

Basic and clinical studies demonstrate that depression is associated with reduced size of brain regions that regulate mood and cognition, including the prefrontal cortex and the hippocampus, and decreased neuronal synapses in these areas. Antidepressants can block or reverse these neuronal deficits,...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Duman, Ronald S., Aghajanian, George K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424898/
https://ncbi.nlm.nih.gov/pubmed/23042884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1222939
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