Identification of essential residues for binding and activation in the human 5-HT(7(a)) serotonin receptor by molecular modeling and site-directed mutagenesis

The human 5-HT(7) receptor is expressed in both the central nervous system and peripheral tissues and is a potential drug target in behavioral and psychiatric disorders. We examined molecular determinants of ligand binding and G protein activation by the human 5-HT(7(a)) receptor. The role of severa...

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Veröffentlicht in:Front Behav Neurosci
Hauptverfasser: Impellizzeri, Agata Antonina Rita, Pappalardo, Matteo, Basile, Livia, Manfra, Ornella, Andressen, Kjetil Wessel, Krobert, Kurt Allen, Messina, Angela, Levy, Finn Olav, Guccione, Salvatore
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2015
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424842/
https://ncbi.nlm.nih.gov/pubmed/26005408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2015.00092
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