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The atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT(7) receptors
BACKGROUND AND PURPOSE: Classically, ligands of GPCRs have been classified primarily upon their affinity and efficacy to activate a signal transduction pathway. Recent reports indicate that the efficacy of a particular ligand can vary depending on the receptor-mediated response measured (e.g. activa...
Shranjeno v:
| izdano v: | Br J Pharmacol |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
John Wiley & Sons, Ltd
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4523340/ https://ncbi.nlm.nih.gov/pubmed/25884989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13169 |
| Oznake: |
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