The atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT(7) receptors

BACKGROUND AND PURPOSE: Classically, ligands of GPCRs have been classified primarily upon their affinity and efficacy to activate a signal transduction pathway. Recent reports indicate that the efficacy of a particular ligand can vary depending on the receptor-mediated response measured (e.g. activa...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Andressen, K W, Manfra, O, Brevik, C H, Ulsund, A H, Vanhoenacker, P, Levy, F O, Krobert, K A
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523340/
https://ncbi.nlm.nih.gov/pubmed/25884989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13169
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